I recently wrote about relationship. Rabbi Nathan Lopes Cardozo published, just this week, a very deep article about loneliness, https://www.facebook.com/notes/rabbi-dr-nathan-lopes-cardozo/israels-security-and-the-need-for-strangerhood/339688556063212.
Longing creates motivation. It can also create despair, but despair itself, rather than immobilizing, has the potential to force one, each and every day, to overcome this despair, to find the beauty and value and love that is in the world if we only acknowledge it.